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KMID : 0358420070500101354
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Korean Journal of Obstetrics and Gynecology
2007 Volume.50 No. 10 p.1354 ~ p.1362
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Increased protein carbonyls as markers for oxidative stress in amniotic fluid of preeclamptic women at term
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Kim Byoung-Jae
Park Joong-Shin
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Abstract
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Objective: To determine if the content of protein carbonyls in amniotic fluid is elevated in preeclamptic women at term.
Methods: A case-control study was conducted to compare contents of protein carbonyls in term amniotic fluid (gestational age at amniocentesis > or = 37 wks) among women who were healthy pregnant, preeclamptic and chronic hypertensive. Protein carbonyls were measured by specific immunoassay. Nonparametric techniques were used for statistical analysis.
Results : 1) The median amniotic fluid protein carbonyl of preeclamptic women was significantly higher than that of normal pregnant women (median 0.663 nmol/mg, range 0.013-1.726 nmol/mg vs. median 0.395 nmol/mg, range 0.069-1.503 nmol/mg, p<.05). 2) There was no significant difference in the amniotic fluid protein carbonyl level between women with chronic hypertension and normal pregnant women (median 0.823 nmol/mg, range 0.064-1.575 nmol/mg vs. median 0.395 nmol/mg, range 0.069-1.503 nmol/mg, p=.14). 3) The median amniotic fluid protein carbonyl showed tendency to increase with severity of preeclampsia without reaching statistical significance (normal pregnancy, median 0.395 nmol/mg, range 0.069-1.503 nmol/mg; mild preeclampsia, median 0.663 nmol/mg, range 0.013-1.054 nmol/mg; severe preeclampsia, median 0.842 nmol/mg, 0.391-1.726 nmol/mg; p=.07). The median protein carbonyl in amniotic fluid of women with severe preeclampsia was significantly higher than that of normal pregnant women (median 0.842 nmol/mg, range 0.391-1.726 nmol/mg vs. median 0.395 nmol/mg, range 0.069-1.503 nmol/mg, p<.05).
Conclusion: The protein carbonyls increased in amniotic fluid of women with preeclampsia, but not chronic hypertension at term.
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KEYWORD
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Preeclampsia, Amniotic fluid, Protein carbonyl formation, Oxidative stress, Hypertension
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